Atualização sobre o uso de probióticos no tratamento de doenças neurológicas

  • Mateus Marcos Cavalcante
  • Iara Leão Luna de Souza

Resumo

A microbiota do sistema digestório pode ter relação com o surgimento de diferentes doenças do sistema nervoso. Diante disto, surgiu a hipótese segundo a qual seria viável tratar pacientes portadores dessas doenças com probióticos. O objetivo deste artigo é informar à comunidade científica sobre o uso de microrganismos no tratamento de doenças neurológicas, ao listar características dos probióticos e demonstrar seu uso na terapêutica dessas doenças para avaliar sua eficiência. A partir de pesquisas em bases de dados on-line (PubMed, LILACS, Scielo e Science direct) em português e inglês, selecionaram-se 17 estudos, e a maioria constatou efeitos benéficos dos probióticos no tratamento de algumas doenças neurológicas. Entretanto, ainda é muito cedo para afirmar que se pode utilizar probióticos na terapia, adjunta ou isoladamente, visto que os efeitos observados não são suficientemente significativos para justificar o uso.

Palavras-chave: probióticos; Alzheimer; Parkinson; depressão; ansiedade.

Abstract

The digestive’s system microbiota can be related to different nervous system diseases. Therefore, the hypothesis that it would be feasible to treat patients with these diseases with probiotics has arisen. This article objective is to inform the scientific community about microorganisms' use in neurological diseases’ treatment, by listing probiotics characteristics and demonstrating their use in these diseases’ treatment to evaluate their efficiency. From searches in online databases (PubMed, LILACS, Scielo and Science direct) in Portuguese and English, 17 studies were selected, and most found beneficial effects of probiotics in some neurological diseases’ treatment. However, it is still too early to say that probiotics can be used in therapy, adjunctively or alone, since the effects observed are not significant enough to justify their use.

Keywords: probiotics; Alzheimer; Parkinson; depression; anxiety.

Resumen

La microbiota del sistema digestivo puede tener relación con el surgimiento de diferentes enfermedades del sistema nervioso. Frente a eso, surge la hipótesis según la cual sería viable tratar a pacientes portadores de esas enfermedades con probiótico. El objetivo de este artículo es informar a la comunidad científica sobre el uso de microorganismos en el tratamiento de enfermedades neurológicas, presentando características de los probióticos y demostrando su uso en la terapia de esas enfermedades para evaluar su eficiencia. A partir de investigaciones en bases de datos online (PubMed, LILACS, Scielo y Science direct), en portugués e inglés, se seleccionaron 17 estudios; la mayoría constató efectos benéficos de los probióticos en el tratamiento de algunas enfermedades neurológicas. Sin embargo, aún es temprano para afirmar que se pueden utilizar probióticos en la terapia, en forma conjunta o solos, visto que los efectos observados no son suficientemente significativos para justificar su uso.

Palabras-clave: probióticos; Alzheimer; Parkinson; depresión; ansiedad.

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Publicado
2021-10-21
Seção
Artigos