Potencial terapêutico do fucus vesiculosus l. em doenças metabólicas: uma revisão integrativa
DOI:
https://doi.org/10.22169/rbpics.v5n9.1514Resumo
A espécie Fucus vesiculosus L., uma macroalga marrom, tem ganhado destaque devido aos seus compostos bioativos, como fucoidanos, florotaninos e iodo, conhecidos por seus potenciais benefícios à saúde. A esses compostos são atribuídas atividades antioxidantes, antiobesidade, antidiabéticas, antienvelhecimento, antimicrobianas, anti-inflamatórias e antitumorais. Dada a importância clínica da busca por opções de tratamento naturais e seguras para o tratamento das doenças metabólicas, incluindo obesidade, diabetes e hipertensão, esta Revisão Integrativa de Literatura busca explorar os efeitos de Fucus vesiculosus L. e suas possíveis aplicações na prevenção e tratamento dessas condições, contribuindo para o desenvolvimento de novas abordagens terapêuticas.
Palavras-chave: Fucus vesiculosus; doenças metabólicas; compostos bioativos; atividades terapêuticas; revisão integrativa.
Abstract
Fucus vesiculosus L., a brown macroalga, has gained prominence due to its bioactive compounds, such as fucoidans, phlorotannins, and iodine, known for their potential health benefits. These compounds are associated with antioxidant, anti‑obesity, antidiabetic, anti‑aging, antimicrobial, anti‑inflammatory, and antitumor activities. Given the clinical importance of searching for natural and safe treatment options for metabolic diseases, including obesity, diabetes, and hypertension, this Integrative Literature Review aims to explore the effects of Fucus vesiculosus L. and its possible applications in the prevention and treatment of these conditions, contributing to the development of new therapeutic approaches.
Keywords: Fucus vesiculosus; metabolic diseases; bioactive compounds; therapeutic activities; integrative review.
Resumen
La especie Fucus vesiculosus L., una macroalga parda, ha ganado protagonismo debido a sus compuestos bioactivos, como los fucoidanos, florotaninos y yodo, conocidos por sus potenciales beneficios para la salud. A estos compuestos se les atribuyen actividades antioxidantes, antiobesidad, antidiabéticas, antienvejecimiento, antimicrobianas, antiinflamatorias y antitumorales. Dada la importancia clínica de la búsqueda de opciones de tratamiento naturales y seguras para las enfermedades metabólicas, incluyendo obesidad, diabetes e hipertensión, esta Revisión Integrativa de la Literatura busca explorar los efectos de Fucus vesiculosus L. y sus posibles aplicaciones en la prevención y el tratamiento de estas condiciones, contribuyendo al desarrollo de nuevos enfoques terapéuticos.
Palabras clave: Fucus vesiculosus; enfermedades metabólicas; compuestos bioactivos; actividades terapéuticas; revisión integradora.
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Referências
AHMED, N. et al. Comprehensive exploration of marine algae diversity, bioactive compounds, health benefits, regulatory issues, and food and drug applications. Measurement: Food, v. 14, p. 100163, 1 jun. 2024. DOI: https://doi.org/10.1016/j.meafoo.2024.100163. Disponível em: https://www.sciencedirect.com/science/article/pii/S2772275924000303. Acesso em: 17 fev. 2025.
DE MARTIN, S. et al. The Brown Algae Fucus vesiculosus and Ascophyllum nodosum Reduce Metabolic Syndrome Risk Factors: A Clinical Study. Natural Product Communications, v. 13, n. 12, p. 1747-1750, 2018. DOI:10.1177/1934578X1801301228. Disponível em: https://www.research.unipd.it/handle/11577/3286568. Acesso em: 17 fev. 2025.
DEROSA, G. et al. Ascophyllum nodosum and Fucus vesiculosus on glycemic status and on endothelial damage markers in dysglicemic patients. Phytotherapy Research, v. 33, n. 3, p. 791-797, 2019. DOI: 10.1002/ptr.6272 Disponível em: https://pubmed.ncbi.nlm.nih.gov/30714233/. Acesso em: 17 fev. 2025.
GABBIA, D. et al. A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH. Marine Drugs, v. 20, n. 9, p. 572, 2022. DOI: doi.org. Disponível em: pubmed.ncbi.nlm.nih.gov. Acesso em: 17 fev. 2025.
GABBIA, D. et al. The phytocomplex from Fucus vesiculosus and Ascophyllum nodosum controls postprandial plasma glucose levels: An in vitro and in vivo study in a mouse model of NASH. Marine Drugs, v. 15, n. 2, p. 41, 2017. DOI: 10.3390/md20090572. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36135761/. Acesso em: 17 fev. 2025.
GABBIA, D.; DE MARTIN, S. Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases. Molecules, v. 25, n. 18, p. 4182, 12 set. 2020. DOI: 10.3390/molecules25184182. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32932674/. Acesso em: 17 fev. 2025.
GANESAN, A. R. et al. Seaweed nutraceuticals and their therapeutic role in disease prevention. Food Science and Human Wellness, v. 8, n. 3, p. 252-263, 2019. DOI: https://doi.org/10.1016/j.fshw.2019.08.001. Disponível em: https://www.sciencedirect.com/science/article/pii/S2213453019300254. Acesso em: 17 fev. 2025.
JANG, H. et al. Exploring the health benefits and concerns of brown seaweed consumption: A comprehensive review of bioactive compounds in brown seaweed and its potential therapeutic effects. Journal of Agriculture and Food Research, v. 17, p. 101215, 1 set. 2024. Disponível em: https://agris.fao.org/search/ru/records/675977fbc7a957febdf7e6b5. Acesso em: 17 fev. 2025.
KIM, Y. R. et al. Brown Seaweed Consumption as a Promising Strategy for Blood Glucose Management: A Comprehensive Meta-Analysis. Nutrients, v. 15, n. 23, p. 4987, 2023. DOI: 10.3390/nu15234987. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38068845/. Acesso em: 17 fev. 2025.
LIU, H.; GU, L. Phlorotannins from brown algae (Fucus vesiculosus) inhibited the formation of advanced glycation endproducts by scavenging reactive carbonyls. Journal of Agricultural and Food Chemistry, v. 60, n. 5, p. 1326-1334, 2012. DOI: DOI: 10.1021/jf204112f. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22248148/. Acesso em: 17 fev. 2025.
LIU, J. et al. Fucoidan alleviates high sucrose-induced metabolic disorders and enhances intestinal homeostasis through modulation of Notch signaling. Journal of Advanced Research, 2024. DOI: https://doi.org/10.1016/j.jare.2024.05.034. Disponível em: https://www.sciencedirect.com/science/article/pii/S2090123224002248. Acesso em: 17 fev. 2025.
MSD MANUAL. Síndrome metabólica. Disponível em: www.msdmanuals.com. Acesso em: 17 fev. 2025.
MURRAY, M. et al. A single-dose of a polyphenol-rich Fucus vesiculosus extract is insufficient to blunt the elevated postprandial blood glucose responses exhibited by healthy adults in the evening: A randomised crossover trial. Antioxidants, v. 8, n. 2, p. 49, 2019. DOI: 10.3390/antiox8020049. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30813480/. Acesso em: 17 fev. 2025.
MURRAY, M. et al. The impact of a single dose of a polyphenol-rich seaweed extract on postprandial glycaemic control in healthy adults: A randomised cross-over trial. Nutrients, v. 10, n. 3, p. 270, 2018. DOI: 10.3390/nu10030270. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29495492/. Acesso em: 17 fev. 2025.
NOVA, P. et al. Chemical and Antioxidant Properties of Solvent and Enzyme-Assisted Extracts of Fucus vesiculosus and Porphyra dioica. Marine Drugs, v. 22, n. 7, art. 319, 2024. DOI: https://doi.org/10.3390/md22070319. Disponível em: https://www.mdpi.com/1660-3397/22/7/319. Acesso em: 17 fev. 2025.
OBLUCHINSKAYA, E. D. et al. Optimization of extraction of phlorotannins from the arctic fucus vesiculosus using natural deep eutectic solvents and their HPLC profiling with tandem high-resolution mass spectrometry. Marine Drugs, v. 21, n. 5, p. 263, 2023. DOI: https://doi.org/10.3390/md21050263. Disponível em: https://www.mdpi.com/1660-3397/21/5/263. Acesso em: 17 fev. 2025.
PARADIS, M. E. et al. A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Applied Physiology, Nutrition, and Metabolism, v. 36, n. 6, p. 913-919, 2011. DOI: 10.1139/h11-115. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22087795/. Acesso em: 17 fev. 2025.
SANTOS, S. A. O. et al. Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety. Processes, v. 9, n. 5, p. 893, 2021. DOI: https://doi.org/10.3390/pr9050893. Disponível em: https://www.mdpi.com/2227-9717/9/5/893. Acesso em: 17 fev. 2025.
SBEM – SOCIEDADE BRASILEIRA DE ENDOCRINOLOGIA E METABOLOGIA. A síndrome metabólica. Disponível em: www.endocrino.org.br. Acesso em: 17 fev. 2025.
SBH – SOCIEDADE BRASILEIRA DE HIPERTENSÃO. Sobre a hipertensão. Disponível em: www.sbh.org.br. Acesso em: 22 fev. 2025.
SILVA, A. M. S. et al. Fucoidan from Fucus vesiculosus L. enhances glucose uptake and modulates adipokine expression in insulin-resistant adipocytes. Food Bioscience, v. 50, p. 103749, 2024.
SOUZA, M. T. et al. Integrative review: what is it? How to do it? Einstein (São Paulo), v. 8, p. 102-106, 2010. DOI: https://doi.org/10.1590/S1679-45082010RW1134. Disponível em: https://www.scielo.br/j/eins/a/ZQTBkVJZqcWrTT34cXLjtBx/?lang=pt. Acesso em: 17 fev. 2025.
TSAI, S. et al. Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor κB activation. Journal of Vascular Surgery, v. 68, n. 6, p. 72S-81S.e1, 1 dez. 2018. DOI: 10.1016/j.jvs.2017.09.042. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29290496/. Acesso em: 17 fev. 2025.
TUNG, Y. T. et al. Ascophyllum nodosum and Fucus vesiculosus Extracts Improved Lipid Metabolism and Inflammation in High-Energy Diet–Induced Hyperlipidemia Rats. Nutrients, v. 14, n. 21, p. 4665, 2022. DOI: 10.3390/nu14214665. Disponível em: https://pubmed.ncbi.nlm.nih.gov/36364926/. Acesso em: 17 fev. 2025.
VODOUHÈ, M. et al. Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects. Marine Drugs, v. 20, n. 3, p. 174, 2022. DOI: 10.3390/md20030174. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35323474/. Acesso em: 17 fev. 2025.
YAMAGATA, K. Prevention of cardiovascular disease through modulation of endothelial cell function by dietary seaweed intake. Phytomedicine Plus, v. 1, n. 2, p. 100026, maio 2021. DOI: https://doi.org/10.1016/j.phyplu.2021.100026. Disponível em: https://www.sciencedirect.com/science/article/pii/S2667031321000087. Acesso em: 17 fev. 2025.
ZUMBI, C. N. et al. Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway. Food Science and Human Wellness, v. 13, n. 3, p. 1711–1728, 8 fev. 2024. Disponível em: https://www.sciopen.com/article/10.26599/FSHW.2022.9250222. Acesso em: 17 fev. 2025.
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